Pontificia Universidad Catolica de Chile
Faculty of Biological Sciences
Mechanisms involved in the metastasis of ovarian and gastric cancer. Role of the coagulation system in the progression and spread of cancer. Translational: Development of molecular diagnostic methods to help in choosing the most appropriate treatment for each patient with cancer.
Cancer genomics, non-coding RNA and signalling. Our group is dedicated to the analysis of microRNA function and to study how genomic alterations may deregulate the function of these genes in cancer. We use this knowledge to improve current cancer therapy and diagnostics.
Cancer immunology and immunotherapy. The research group is searching for molecular signatures associated with tumor-specific immune response in melanoma patients treated with dendritic cell-based immunotherapy.
Our research is focused on development of molecular tools and application of the technologies in different diseases such as prostate and gastric cancers, to identify disease-related protein biomarkers, protein signatures and post-translational modifications with increased specificity and sensitivity. We have also apply our technologies to characterize and detect exosomes as a new class of cancer biomarkers.