Aging is not merely a biological problem, but also an economical, ethical and public health challenge. This increase in life expectancy is the main risk factor for the development of chronic diseases that represent the major burden to the economy of families. Owing to the fact that aging affects most of physiological systems in the human body, we need a multi- and trans-disciplinary approach to tackle some of the most relevant unanswered questions about how humans age. Under this perspective the Chilean-Swedish Forum offers a unique opportunity to bring together basic and clinical researchers interested in aging and gerosciences. Currently a group of researchers at Universidad de Chile are conducting the first longitudinal cohort study that will determine; what are the biological, genetic, medical and social aspects that determine the onset of neurodegenerative diseases. Similar studies had been previously conducted in Sweden.